Download Antimicrobial Resistance and Implications for the 21st by I.W. Fong, Karl Drlica PDF

By I.W. Fong, Karl Drlica

This accomplished, updated quantity defines the problems and gives power ideas to the demanding situations of antimicrobial resistance. The bankruptcy authors are top foreign specialists on antimicrobial resistance between various micro organism, viruses together with HIV and herpes, parasites and fungi. The chapters discover the molecular mechanisms of drug resistance, the immunology and epidemiology of resistance lines, medical implications and implications on learn and shortage thereof, and prevention and destiny instructions.

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Additional resources for Antimicrobial Resistance and Implications for the 21st Century (Emerging Infectious Diseases of the 21st Century)

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2000), Comparative in vivo activity of gemifloxacin in a rat model of respiratory tract infections. J Antimicrob Chem, 45 (S1), 79–85. , (2005). Relationship between increased levofloxacin use and decreased susceptibility of Streptococcus pneumoniae in the United States. Diag Microbiol Infect Dis, 51, 31–37. , (2001), Mutant prevention concentrations of fluoroquinolones for clinical isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother, 45, 433–438. , Agouridas, C. , (1997), Ketolides lack inducibility properties of MLS(B) resistance phenotype.

Agents Chemother. 43: 1756–1758. , Leversedge, K. , (1999), Failure of treatment of pneumonia associated with highly resistant pneumococci in a child. Clin Infect Dis, 29, 462–463. , Etienne, J. , (2000), Characterization of isolates associated with emerging resistance to quinupristin/dalfopristin (Synercid) during a worldwide clinical program. Diagn Microbiol Infect Dis, 37, 57–62. Drlica, K. , (1997), DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev, 61, 377–392. , Soderstrom, M.

This relatively low resistance rate when compared to β-lactams has caused clinicians to consider fluoroquinolones as relatively safe agents in the treatment of pneumococcal infections. Be that as it may, it is worth pointing out that the appearance of resistance during treatment may occur, reflecting spontaneous mutations in QRDR. Such a change could adversely affect the pharmacodynamics of the drug. In a recent review, Fuller and coworkers found 20 published reports of clinical failures with fluoroquinolones used to treat respiratory tract infections due to fluoroquinoloneresistant S.

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